This paper is devoted to trie problem of interrelation between Opet festival and the Heb-Sed of Hatshepsut and Thutmose III. The author points out the three main motifs of Heb-Sed in the scenes of Opet, represented on the walls of Hatshepsuts Red Chapel at Karnak and her temple at Deir el Bahari: the Heb-Sed statues of kings, the ritual Running of the Course with Apis bull and the consecration of obelisks. The presence of such episodes in the Opet program has allowed us to propose that the formation of this festival took place by the time of Hatshepsuts Sed-festival, that was celebrated during her 16 regnal year. The analysis of decoration of Thutmose Ills buildings at Karnak (the Festival Hall of the Akh-menu temple, the wall of the Annals etc.) shows that Hatshepsuts successor had preserved the Heb-Sed rituals in Opet festival and reinforced their connection with the military victories of the pharaoh.